How Long Does 100mg Sildenafil Last In Your Body?

Have you ever wondered how long the effects of 100mg sildenafil last in your body? In this article, we’ll explore the duration of this popular medication commonly used to treat erectile dysfunction. Whether you’re curious about planning your romantic evening or simply want to understand the effects of sildenafil better, we’ll provide you with the information you need to know. So, sit back, relax, and let’s unravel the mystery of how long 100mg sildenafil lasts in your body.

How Long Does 100mg Sildenafil Last In Your Body?

Factors Affecting Duration of Sildenafil

The duration of effectiveness of 100mg sildenafil, also known as Viagra, can vary based on several factors. One of the key factors is your individual body’s metabolism, which determines how quickly the drug is broken down and eliminated from your system. Additionally, other factors such as age, underlying health conditions, and concurrent use of medications can also play a role in the duration of action of sildenafil.

Mechanism of Action

Sildenafil belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. It works by increasing blood flow to the penis, resulting in improved erectile function. When you take 100mg sildenafil, it inhibits the PDE5 enzyme, allowing for increased levels of nitric oxide in the blood vessels of the penis. This leads to relaxation of the smooth muscles and dilation of the arteries, facilitating the flow of blood to the penis and causing an erection.

Metabolism and Excretion of Sildenafil

Once you consume 100mg sildenafil, it is rapidly absorbed into your bloodstream through the digestive system. The liver metabolizes the drug, specifically through the cytochrome P450 3A4 enzyme pathway. The metabolites formed are then eliminated primarily through the feces (approximately 80%) and to a lesser extent through urine (approximately 13%). The elimination process usually takes place within a few hours to a couple of days, depending on your individual metabolism.

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Half-life of Sildenafil

The half-life of sildenafil refers to the time it takes for half of the drug to be eliminated from your body. For 100mg sildenafil, the average half-life is approximately 4 hours. This means that after 4 hours, half of the drug will have been eliminated from your system. However, it’s important to note that the effects of sildenafil can still be felt for a longer duration.

Peak Plasma Concentration

The peak plasma concentration of sildenafil refers to the maximum level of the drug in your bloodstream. For 100mg sildenafil, the peak plasma concentration is reached within 30 to 120 minutes after ingestion. This means that the drug is at its highest concentration in your blood during this timeframe, and you are most likely to experience its effects during this period.

Variation in Individual Response

It is important to recognize that individuals may respond differently to 100mg sildenafil due to variations in metabolism and other factors. While some individuals may experience the desired effects for a longer duration, others may find that the effects wear off sooner. It is crucial to consult with your healthcare provider to determine the optimal dosage and duration of action for your specific needs.

Interaction with Food

The presence of food in your stomach can affect the absorption and onset of action of 100mg sildenafil. Consuming a high-fat meal prior to taking the medication may delay its absorption and onset of action. To ensure the maximum effectiveness and duration of sildenafil, it is recommended to take the medication on an empty stomach or with a light meal.

Factors Affecting Duration of Action

Apart from individual metabolism, several other factors can influence the duration of action of 100mg sildenafil. These factors include the presence of underlying health conditions such as liver or kidney disease, cardiovascular problems, or certain medications that may interfere with the metabolism of sildenafil. It is important to disclose all relevant medical information to your healthcare provider to ensure safe and effective use of the medication.

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Effectiveness and Duration of Different Dosages

The effectiveness and duration of sildenafil can also vary based on the dosage taken. While 100mg is a commonly prescribed dose for erectile dysfunction, lower doses, such as 50mg or 25mg, may be suitable for some individuals. It is important to work closely with your healthcare provider to determine the most appropriate dosage that provides the desired effect for the desired duration.


In conclusion, the duration of action for 100mg sildenafil can range from a few hours to a few days, depending on individual factors and metabolism. It is important to note that sildenafil alone does not cause an erection and requires sexual stimulation to be effective. It is always recommended to consult with a healthcare provider for personalized advice on the optimal dosage and duration of sildenafil for your needs. Remember, open communication with your healthcare provider will ensure the safe and effective use of this medication for treating erectile dysfunction.